Timothy W.
Secomb, Ph.D.
Publications
Books
1. Barth, F.G., Humphrey, J.A.C., and Secomb, T.W., eds. Sensors and Sensing in Biology and Engineering, Springer-Verlag Wien, 2003, 399 pp.
Invited Review Articles
1. Skalak, R., Keller, S.R. and Secomb, T.W. Mechanics of blood flow. J.
Biomech.
2. Secomb, T.W. Red blood cell mechanics and capillary blood rheology. Cell
Biophysics 18: 231-251 (1991).
3. Pries, A.R., Secomb, T.W. and Gaehtgens, P. Biophysical aspects of blood
flow in the microvasculature. Cardiovascular Res. 32: 654-667 (1996).
4. El-Kareh, A.W. and Secomb, T.W. Theoretical models for drug delivery to
solid tumors. Critical Reviews in Biomedical Engineering 25: 503-571 (1997)
5. Gillies, R.J., Schornack, P.A., Secomb, T.W. and Raghunand, N. Causes and
effects of heterogeneous perfusion in tumors. Neoplasia 1: 197-207 (1999).
6. Pries, A.R., Secomb, T.W., and Gaehtgens, P. The endothelial surface layer.
Pflügers Archiv: European Journal of Physiology 440: 653-666 (2000)
7. Dewhirst, M.W., Klitzman, B., Braun, R.D., Brizel, D.M., Haroon, Z.A. and
Secomb, T.,W. Review of methods used to study oxygen transport at the
microcirculatory level. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 237-255
(2000)
8. Pries, A.R. and Secomb, T.W. Structural adaptation of microvascular networks
and development of hypertension. Microcirculation 9: 305-314 (2002).
9. Secomb, T.W. and Pries, A.R. Information transfer in microvascular networks.
Microcirculation 9: 377-387 (2002).
10. Zakrzewicz, A.., Secomb, T.W. and Pries, A.R. Angioadaptation: Keeping the
vascular system in shape. News in Physiological Sciences 17: 197-201 (2002).
11. Pries, A.R. and Secomb, T.W. Control of blood vessel structure: Insights from theoretical models. Am. J. Physiol., 288: H1010-1015 (2005).
12. Secomb, T.W., Hsu, R. and Pries, A.R. Tribology of capillary blood flow. Journal of Engineering Tribology, 220: 767-774 (2006).
Refereed Journal Articles
1. Goodman, P. and Secomb, T.W. Identification of
enantiomorphously related space groups by electron diffraction. Acta Cryst.
A33: 126-133 (1977).
2. Secomb, T.W. Flow in a channel with pulsating walls. J. Fluid Mech. 88:
273-288 (1978).
3. Secomb, T.W. and Rosenblat, S. Torsional oscillations of a non-Newtonian
fluid with a free surface. J. Fluid Mech. 93: 767-780 (1979).
4. Secomb, T.W. and Skalak, R. Surface flow of viscoelastic membranes in
viscous fluids. Q. Jl. Mech. Appl. Math. 35: 233-247 (1982).
5. Secomb, T.W. and Skalak, R. A two-dimensional model for capillary flow of an
asymmetric cell. Microvasc. Res. 24: 194-203 (1982).
6. Secomb, T.W., Fischer, T.M. and Skalak, R. The motion of close-packed red
blood cells in shear flow. Biorheology 20: 283-294 (1983).
7. Secomb, T.W., Chien, S., Jan, K.-M. and Skalak, R. The bulk rheology of
close-packed red blood cells in shear flow. Biorheology 20: 295-309 (1983).
8. Secomb, T.W. and Gross, J.F. Flow of red blood cells in narrow capillaries:
Role of membrane tension. Int. J. Microcirc. Clin. Exp. 2: 229-240 (1983).
9. Stephanoff, K.D., Pedley, T.J., Lawrence, C.J. and Secomb, T.W. Fluid flow
along a channel with an asymmetric oscillating constriction. Nature 305:
692-695 (1983).
10. Wright, S.H. and Secomb, T.W. Epidermal taurine transport in marine
mussels. Amer. J. Physiol. 247: R346-R355 (1984).
11. Secomb, T.W., Skalak, R., Ozkaya, N. and Gross, J.F. Flow of axisymmetric
red blood cells in narrow capillaries. J. Fluid Mech. 163: 405-423 (1986).
12. Wright, S.H. and Secomb, T.W. Epithelial amino acid transport in marine
mussels: Role in net exchange of taurine between gills and sea water. J.
Exp.Biol. 121: 251-270 (1986).
13. Fleischman, G.J., Secomb, T.W. and Gross, J.F. Effect of extravascular
pressure gradients on capillary fluid exchange. Math. Biosciences 81: 145-164
(1986).
14. Fleischman, G.J., Secomb, T.W. and Gross, J.F. The interaction of
extravascular pressure fields and fluid exchange in capillary networks. Math.
Biosciences 82: 141-151 (1986).
15. Secomb, T.W., Pries, A.R. and Gaehtgens, P. Hematocrit fluctuations within
microvessels and estimation of Fahraeus effect. Int. J. Microcirc. Clin. Exp.
5: 335-345 (1987).
16. Secomb, T.W. Flow-dependent rheological properties of blood in capillaries.
Microvasc. Res. 34: 46-58 (1987).
17. Wright, S.H., Secomb, T.W. and Bradley, T.J. Apical membrane permeability
of Mytilus gill: Influence of ultrastructure, salinity and competitive
inhibitors on amino acid fluxes. J. Exp. Biol. 129: 205-230 (1987).
18. Lillioja, S., Young, A.A., Culter, C.L., Ivy, J.L., Abbott, W.G.H., Zawadzki,
J.K., YkiJarvinen, H., Christin, L., Secomb, T.W. and Bogardus, C. Skeletal
muscle capillary density and fiber type are possible determinants of in vivo
insulin resistance in man. J. Clin. Invest. 80: 415-424 (1987).
19. Murata, T. and Secomb, T.W. Effects of shear rate on rouleau formation in
simple shear flow. Biorheology 25: 113-122 (1988).
20. Secomb, T.W. Interaction between bending and tension forces in bilayer
membranes. Biophys. J. 54: 743-746 (1988).
21. Murata, T. and Secomb, T.W. Effects of
aggregation on flow properties of red blood cell suspensions in narrow vertical
tubes. Biorheology 26: 247-259 (1989).
22. Halpern, D. and Secomb, T.W. The squeezing of red blood cells through
capillaries with near-minimal diameters. J. Fluid Mech. 203: 381-400 (1989).
23. Hsu, R. and Secomb, T.W. Motion of non-axisymmetric red blood cells in
cylindrical capillaries. J. Biomechanical Engineering 111: 147-151 (1989).
24. Hsu, R. and Secomb, T.W. A Green's function method for analysis of oxygen
delivery to tissue by microvascular networks. Math. Biosciences. 96: 61-78
(1989).
25. Meyer, J.-U., Burkhard, P.M., Secomb, T.W. and Intaglietta, M. The Prony
spectral line estimation (PSLE) method for the analysis of vascular
oscillations. IEEE Trans. Biomed. Eng. 36: 968-971 (1989).
26. Dewhirst, M.W., Tso, C.Y., Oliver, R., Gustafson, C.S., Secomb, T.W. and
Gross, J.F. Morphologic and hemodynamic comparison of tumor and healing normal
tissue microvasculature. Int. J. Radiation Oncology Biol. Phys. 17: 91-99
(1989).
27. Sugihara-Seki, M., Secomb, T.W. and Skalak, R. Two-dimensional analysis of
two-file flow of red cells along capillaries. Microvasc. Res. 40: 379-393
(1990).
28. Pries, A.R., Secomb, T.W., Gaehtgens, P. and Gross, J.F. Blood flow in
microvascular networks - Experiments and simulation. Circulation Research 67:
826-834 (1990).
29. Dewhirst, M.W., Oliver, R., Tso, C.Y., Gustafson, C.S., Secomb, T.W. and
Gross, J.F. Heterogeneity of tumor microvascular response to radiation. Int. J.
Radiation Oncology Biol. Phys. 18: 559-568 (1990)
30. Halpern, D. and Secomb, T.W. Viscous motion of disc-shaped particles
through parallel-sided channels with near minimal widths. J. Fluid Mech. 231:
545-560 (1991).
31. Hsu, R. and Secomb, T.W. Analysis of oxygen exchange between arterioles and
surrounding capillary-perfused tissue. J. Biomech. Eng. 114: 227-231 (1992).
32. Dewhirst, M.W., Ong, E.T., Klitzman, B., Secomb, T.W., Vinuya, R.Z., Dodge,
R., Brizel, D. and Gross, J.F. Perivascular oxygen tensions in a transplantable
mammary tumor growing in a dorsal flap window chamber. Radiation Research 130:
171-182 (1992).
33. Dewhirst, M.W., Vinuya, R.Z., Ong, E.T., Klitzman, B., Rosner, G., Secomb,
T.W. and Gross, J.F. Effects of bradykinin on the hemodynamics of tumor and
granulating normal tissue microvasculature. Radiation Research 130: 345-354
(1992).
34. Halpern, D. and Secomb, T.W. The squeezing of red blood cells through
parallel-sided channels with near-minimal widths. J. Fluid Mech. 244: 307-322
(1992).
35. Dewhirst, M.W., Ong, E.T., Madwed, D., Klitzman, B., Secomb, T.W., Brizel,
D., Bonaventura, J., Rosner, G., Kavanagh, B., Edwards, J. and Gross, J.F.
Effects of the calcium channel blocker Flunarizine on tumor microvascular
hemodynamics and oxygenation. Radiation Research 132: 61-68 (1992).
36. Secomb, T.W., Hsu, R., Dewhirst, M.W., Klitzman, B. and Gross, J.F.
Analysis of oxygen transport to tumor tissue by microvascular networks. Int. J.
Rad. Onc. Biol. Phys. 25: 481-489 (1993).
37. El-Kareh, A.W., Braunstein, S.L. and Secomb, T.W. Effect of cell
arrangement and interstitial volume fraction on the diffusivity of monoclonal
antibodies in tissue. Biophys. J. 64, 1638-1646 (1993).
38. Secomb, T.W. and Hsu, R. Non-symmetric motion of rigid closely-fitting
particles in fluid-filled tubes. J. Fluid Mech. 257, 403-420 (1993).
39. Secomb, T.W. and El-Kareh, A.W. A model for the motion and sedimentation of
cylindrical re-cell aggregates during slow blood flow in narrow horizontal
tubes. J. Biomech. Eng. 116, 243-249 (1994).
40. Secomb, T.W. and Hsu, R. Simulation of oxygen transport in skeletal muscle:
diffusive exchange between arterioles and capillaries. Am. J. Physiol. 267,
H1214-1221 (1994).
41. Dewhirst, M.W., Secomb, T.W., Ong, E.T., Hsu,
R. and Gross, J.F. Determination of local oxygen consumption rates in tumors.
Cancer Research 54, 3333-3336, (1994).
42. Pries, A.R., Secomb, T.W., Gessner, T., Sperandio, M.B., Gross, J.F. and
Gaehtgens, P. Resistance to blood flow in microvessels in vivo. Circ. Res. 75,
904-915 (1994).
43. El-Kareh, A.W. and Secomb, T.W. Effect of increasing vascular hydraulic
conductivity on delivery of macromolecular drugs to tumor cells. Int. J. Rad.
Onc. Biol. Physics 32, 1419-1423 (1995).
44. Secomb, T.W., Hsu, R., Ong, E.T., Gross, J.F. and Dewhirst, M.W. Analysis
of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta
Oncologica 34, 313-316 (1995).
45. Pries, A.R., Secomb, T.W., and Gaehtgens, P. Design principles of vascular
beds. Circ. Res. 77, 1017-1023 (1995).
46. Pries, A.R., Secomb, T.W., and Gaehtgens, P. Structure and hemodynamics of
microvascular networks: Heterogeneity and correlations. Am. J. Physiol. 269,
H1713-H1722 (1995).
47. Secomb, T.W. and Hsu, R. Red blood cell mechanics and functional capillary
density. Int. J. Microcirc. Clin. Exp. 15:250-254 (1995).
48. Pries, A.R., Secomb, T.W., and Gaehtgens, P. The relationship between
structural and hemodynamic heterogeneity in microvascular networks. Am. J.
Physiol. 270, H545-553 (1996).
49. El-Kareh, A.W. and Secomb, T.W. Stokes flow impinging on a spherical cap on
a plane wall. Q. Jl. Mech. Appl. Math. 49:179-193 (1996).
50. Dewhirst, M.W., Ong, E.T., Rosner, G.L., Rehmus, S.W., Shan, S., Braun,
R.D., Brizel, D.M. and Secomb, T.W. Arteriolar oxygenation in tumor and
subcutaneous arterioles: effects of inspired air oxygen content. Br. J. Cancer
74, S241-S246 (1996).
51. Dewhirst, M.W., Kimura, H., Rehmus, S.W., Braun, R.D., Papahadjopoulos, D.,
Hong, K. and Secomb, T.W. Microvascular studies on the origins of
perfusion-limited hypoxia. Br. J. Cancer 74, S247-S251 (1996).
52. Secomb, T.W. and Hsu, R. Analysis of red blood cell motion through
cylindrical micropores: effects of cell properties. Biophys. J. 71, 1095-1101
(1996)
53. Secomb, T.W. and Hsu, R. Motion of red blood cells in capillaries with
variable cross-sections. J. Biomech.
54. Kimura, H., Ong, E.T., Hsu, R., Braun, R., Secomb, T.W., Papahadjopoulos,
D., Hong, K. and Dewhirst, M.W. Fluctuations in red cell flux in tumor
microvessels can lead to intermittent periods of hypoxia and reoxygenation in
tumor parenchyma. Cancer Res. 56: 5522-5528 (1996).
55. Secomb, T.W. and Hsu, R. Resistance to blood flow in non-uniform
capillaries. Microcirculation 4: 421-427 (1997).
56. Pries, A.R., Secomb, T.W., Sperandio, M. and Gaehtgens, P. Effects of
plasma composition on microvascular blood flow resistance: Implications of
hemodilution studies. Cardiovasc. Res. 37: 225-235 (1998).
57. Secomb, T.W., Hsu, R. and A.R. Pries. A model for red blood cell motion in
glycocalyx-lined capillaries. Am. J. Physiol. 274: H1016 -H1022 (1998).
58. Pries, A.R., Secomb, T.W., Jacobs, H., Sperandio, M., Osterloh, K. and
Gaehtgens, P. Microvascular blood flow resistance in vivo: Role of the
endothelial surface layer. Am. J. Physiol. 273: H2272-2279 (1997).
59. Pries, A.R., Secomb, T.W., and Gaehtgens, P. Structural adaptation and
stability of microvascular networks: theory and simulations. Am. J. Physiol.
275: H349-H360 (1998).
60. Pries, A.R., Secomb, T.W., and Gaehtgens, P. Structural autoregulation of
terminal vascular beds: Vascular adaptation and development of hypertension.
Hypertension 33: 153-161 (1999).
61. Dunn, T.J., Braun, R.D., Rhemus, W.E., Rosner,
G.L., Secomb, T.W., Tozer, G.M., Chaplin, D.J. and Dewhirst, M.W. The effects
of hyperoxic and hypercarbic gases on tumour blood flow. Br. J. Cancer 80,
117-126 (1999).
62. El-Kareh, A.W. and Secomb, T.W. A model for red blood cell motion in
bifurcating microvessels. Int. J. Multiphase Flow 26: 1545-1564 (2000).
63. Secomb, T.W., Hsu, R., Beamer, N.B. and Coull, B.M. Theoretical simulation
of oxygen transport to brain by networks of microvessels: effects of oxygen
supply and demand on tissue hypoxia. Microcirculation 7, 237-247 (2000).
64. Pries, A.R. and Secomb, T.W. Microcirculatory network structures and
models. Ann. Biomed. Eng. 28, 916-921 (2000).
65. El-Kareh, A.W. and Secomb, T.W. A mathematical model for comparison of
bolus injection, continuous infusion, and liposomal delivery of doxorubicin to
tumor cells. Neoplasia 2, 325-338 (2000).
66. Secomb, T.W. and El-Kareh, A.W. A theoretical model for the elastic
properties of very soft tissues. Biorheology 38, 305-17 (2001).
67. Secomb, T.W., Hsu R., and Pries, A.R. Effect of the endothelial surface
layer on transmission of fluid shear stress to endothelial cells. Biorheology
38, 143-150 (2001).
68. Secomb, T.W., Hsu, R. and Pries, A.R. Motion of red blood cells in a
capillary with an endothelial surface layer: effect of flow velocity. Am. J.
Physiol. 281, H629-H636 (2001)
69. Pries, A.R., Reglin, B. and Secomb, T.W. Structural adaptation of
microvascular networks: Functional roles of adaptive responses. Am. J. Physiol.
281, H1015-1025 (2001).
70. Snyder, S.A., Lanzen, J.L., Braun, R.D., Rosner, G., Secomb, T.,W.,
Biaglow, J., Brizel, D.M., Dewhirst, M.W. Simultaneous administration of
glucose and hyperoxic gas achieves greater improvement in tumor oxygenation
than hyperoxic gas alone. Int. J. Rad. Onc. Biol. Phys. 51, 494-506 (2001).
71. West, C.A, He, C., Su, M., Secomb, T.W., Konerding, M.A., Young, A.J. and
Mentzer, S.J. Topographic changes in the inflammatory microcirculation
associated with lymphocyte slowing and transmigration. Am. J. Physiol.281,
H1742-1750 (2001).
72. McGuire, B.J. and Secomb, T.W. A theoretical model for oxygen transport in
skeletal muscle under conditions of high oxygen demand. J. Applied Physiology
91:2255-2265 (2001).
73. Li, X., Su, M., West, C.A., He, C., Swanson, S.J., Secomb, T.W. and
Mentzer, S.J. Effect of shear stress on efferent lymph-derived lymphocytes in
contact with activated endothelial monolayers. In Vitro Cell Dev Biol, 37,
599-605 (2001).
74. Pries, A.R., Reglin, B. and Secomb, T.W. Structural adaptation of vascular
networks: Role of the pressure response. Hypertension, 38:1476-9 (2001).
75. Goriely, A.R., Secomb, T.W. and Tolbert, L.P. Effect of the glial envelope
on extracellular K+ diffusion in olfactory glomeruli. J. Neurophysiol. 87:
1712-1722 (2002).
76. Kavanagh, B.D., Secomb, T.W., Hsu, R., Lin, P.-S., Venitz, J. and Dewhirst,
M.W. A theoretical model for the effects of reduced hemoglobin-oxygen affinity
on tumor oxygenation. Int. J. Rad. Onc. Biol. Phys. 53, 172-179 (2002).
77. Secomb, T.W., Hsu, R. and Pries, A.R. Blood flow and red blood cell
deformation in nonuniform capillaries: effects of the endothelial surface
layer. Microcirculation 9: 189-196 (2002).
78. El-Kareh, A.W. and Secomb, T.W. A mathematical model for cisplatin cellular
pharmacodynamics. Neoplasia 5: 161-169 (2003).
79. Pries, A.R., Reglin, B. and Secomb, T.W. Structural response of
microcirculatory networks to changes in demand: Information transfer by shear
stress. Am. J. Physiol., 284: H2204–H2212 (2003).
80. Secomb, T.W., Konerding, M.A., West,
81. Erickson, C.P., Braun, R.D., Yu, D., Lanzen,
J., Wilson, D., Brizel, D.M., Secomb, T.W., Biaglow, J.E., Dewhirst, M.W.
Effect of longitudinal oxygen gradients on effectiveness of manipulation of
tumor oxygenation. Cancer Res. 63: 4705-4712 (2003).
82. Lo, A., Fuglevand, A.J. and Secomb, T.W. Oxygen delivery to skeletal muscle
fibers: Effects of microvascular unit structure and control mechanisms. Am. J.
Physiol., 285: H955-H963 (2003).
83. McGuire, B.J. and Secomb, T.W. Estimation of capillary density in human
skeletal muscle based on maximal oxygen consumption rates. Am. J. Physiol.,
285: H2382-2391 (2003).
84. Pries, A.R. and Secomb, T.W. Rheology of the microcirculation. Clin. Hemorheol. Microcirc. 29: 143-148
(2003).
85. Secomb, T.W., Hsu, R. and Dewhirst, M.W. Synergistic effects of hyperoxic gas
breathing and reduced oxygen consumption on tumor oxygenation: A theoretical model. Int. J. Rad. Onc. Biol. Phys., 59: 572-578
(2004).
86. El-Kareh, A.W. and Secomb, T.W. A theoretical model for intraperitoneal
delivery of cisplatin and the effect of hyperthermia on drug penetration
distance. Neoplasia,6: 117-127 (2004).
87. Lo, A., Fuglevand, A.J. and Secomb, T.W. Theoretical simulation of K+-based mechanisms
for regulation of capillary perfusion in skeletal muscle. Am. J. Physiol., 287: H833-840 (2004).
88. Cárdenas-Navia, L.I., Yu, D., Yarmolenko, P.,
Braun, R.D., Brizel, D.M., Secomb, T.W. and Dewhirst, M.W. Characterization of spatial pO2 frequency
distributions and kinetics of pO2 fluctuations during air and oxygen breathing
for two rodent tumor lines. Cancer Res.,
64: 6010-6017 (2004).
89. McGuire, B.J. and Secomb, T.W.
Theoretical predictions of maximal oxygen consumption in hypoxia:
effects of transport limitations.
Respiratory Physiology and Neurobiology, 143: 87-97 (2004).
90. Secomb, T.W., Hsu, R., Park, E.Y.H. and
Dewhirst, M.W. Green's function methods
for analysis of oxygen delivery to tissue by microvascular networks. Annals of Biomedical Engineering, 32:
1519-1529 (2004).
91. Gruionu, G., Hoying, J.B., Pries, A.R.. and
Secomb, T.W. Structural remodeling of
the mouse gracilis artery following chronic alteration in blood supply. Am. J. Physiol., 288: H2047-2054 (2005).
92.
Carlson, B.E. and Secomb, T.W. A theoretical model for the myogenic
response based on the mechanics of vascular smooth muscle. Microcirculation, 12: 327-338 (2005).
93.
Gruionu, G., Hoying, J.B., Gruionu, L.G., Laughlin, M.H. and Secomb,
T.W. Structural adaptation increases
predicted perfusion capacity following vessel obstruction in the arteriolar
arcade network of pig skeletal muscle.
Am. J. Physiol., 288: H2778-2784 (2005).
94. El-Kareh, A.W. and Secomb, T.W. Two-mechanism peak-concentration model for
cellular pharmacodynamics of doxorubicin.
Neoplasia, 7: 705-713 (2005).
95. Pries, A.R., Reglin, B. and Secomb, T.W. Remodeling of blood vessels:
responses of diameter and wall thickness to hemodynamic and metabolic stimuli.
Hypertension, 46: 725-731 (2005). See
commentary: Modeling the vasculature: A
judicious approach? by M.J. Mulvany. Hypertension 46:652-653, 2005.
96. Pries,
A.R. and Secomb, T.W. Microvascular
blood viscosity in vivo and the endothelial surface layer. Am. J. Physiol., 289: H2657-H2664 (2005).
97. Lanzen, J., Braun, R.D., Klitzman, B., Brizel,
D., Secomb, T.W., Dewhirst, M.W. Direct
demonstration of instabilities in oxygen concentrations within the
extravascular compartment of an experimental tumor. Cancer Research, 66: 2219-2223 (2006).
98. Hicks, K.O, Pruijn, F.B., Secomb, T.W., Hay,
M.P., Hsu, R., Brown, J.M., Denny, W.A., Dewhirst, M.W.,
99. Skotheim, J.M.
and Secomb, T.W. Red blood cells
and other non-spherical capsules in shear flow: oscillatory dynamics and the
tank-treading-to-tumbling transition. To
appear in Physical Rev. Letters.
100. Styp-Rekowska, B., Mecha Disassa, N., Reglin,
B.,
101. Goriely, A.R.,
Chapters in Books and Monographs
1. Secomb, T.W. Kinetics of close-packed red blood
cells in shear flow. In: "Mathematical Aspects of Physiology"
(Hoppensteadt, F.C., ed.) American Mathematical Society,
2. Secomb, T.W. and Skalak, R. Rheology of highly concentrated red blood cell
suspensions. In: "1981 Advances in Bioengineering" (
3. Secomb, T.W. and Gross, J.F. Theory of microvascular hematocrit
fluctuations. In "Progress in Microcirculation Research II"
(Courtice, F.C., Garlick, D.G. and Perry, M.A. eds.) Committee in Postgraduate
Medical Education,
4. Secomb, T.W. Mathematical modelling of convective capillary transport:
Virtues and difficulties. In "Progress in Microcirculation Research
II" (Courtice, F.C., Garlick, D.G. and Perry, M.A. eds.) Committee in
Postgraduate Medical Education,
5. Skalak, R., Ozkaya, N. and Secomb, T.W. Biomechanics of capillary blood
flow. In "Frontiers in Biomechanics" (Schmid-Schonbein, G.W., Woo,
S.L-Y., and Zweifach, B.W. eds.) Springer,
6. Secomb, T.W. Mechanics of red blood cells in capillaries. In: "1986
Advances in Bioengineering" (
7. Secomb, T.W., Fleischman, G.J., Papenfuss, H.-D., Intaglietta, M. and Gross,
J.F. Effects of reduced perfusion and hematocrit on flow distribution in
capillary networks. In: "Progress in Applied Microcirculation Vol 12"
Karger,
8. Secomb, T.W., Wu, N.-Z., Papenfuss H.-D. and Gross, J.F. Role of red blood
cells in determining flow distribution and flow cessation in capillary
networks. In: "Microcirculation - an update, vol. 1" (Tsuchiya, M.,
Asano, M., Mishima, Y. and Oda, M., eds) Elsevier,
9. Secomb, T.W. and Hsu., R. Analysis of oxygen delivery to tissue by
microvascular networks. In "Oxygen Transport to Tissue, X"
(Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K. and Bruley, D.F., eds.)
Plenum,
10. Secomb, T.W., Pries, A.R., Gaehtgens, P. and Gross, J.F. Theoretical and
experimental analysis of hematocrit distribution in microcirculatory networks.
In "Microvascular Mechanics", ed. J.S. Lee and T.C. Skalak, Springer,
11. Secomb. T.W., Intaglietta, M. and Gross, J.F. Effects of vasomotion on
microcirculatory mass transport: Theoretical Predictions. In "Progress in
Applied Microcirculation Vol. 15: Vasomotion and Flow Modulation in the
Microcirculation", ed. M. Intaglietta, 1989, pp. 49-61.
12. Gross, J.F. and Secomb, T.W. Rheological behavior of blood in ischemia.
Advances in Vascular Pathology 1990, eds. A. Strano and S. Novo. Elsevier,
1990, pp. 217-222.
13. Secomb, T.W., Hsu, R. and Dewhirst, M.W. Models for oxygen exchange between
microvascular networks and surrounding tissue. In "Advances in Biological
Heat and Mass Transfer 1992", ed. J.J. McGrath. Am. Soc. Mech. Eng., 1992,
pp. 121-127.
14. Secomb, T.W. The mechanics of blood flow in capillaries. In
"Contemporary Mathematics 141: Fluid Dynamics in Biology," ed. A.Y.
Cheer and C.P. van Dam, American Mathematical Society, Providence, R.I., 1993,
pp. 519-542.
15. Secomb, T.W. and El-Kareh, A.W. Slow blood flow in narrow tubes: Effects of
aggregation, asymmetry and sedimentation. In "1993 Advances in
Bioengineering", ed. J.M. Tarbell. Am. Soc. Mech. Eng., 1993, pp. 381-384.
16. Secomb, T.W. Mechanics of blood flow in the microcirculation. In
"Biological Fluid Dynamics." ed. C.P. Ellington and T.J. Pedley.
Company of Biologists,
17. Secomb, T.W., Pries, A.R. and Gaehtgens, P. Architecture and hemodynamics
of microvascular networks. In "Biological Flows", ed. M.Y. Jaffrin
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18. Dewhirst, M., Ong, E., Smith, B, Evans, S., Secomb, T. and
19. Dewhirst, M. and Secomb, T. Concepts in tumor oxygen transport. In
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20. Secomb, T.W., Hsu, R., Braun, R.D., Ross, J.R., Gross, J.F. and Dewhirst,
M.W. Theoretical simulation of oxygen transport to tumors by three-dimensional
networks of microvessels. In "Oxygen Transport to Tissue XX," ed.
A.G. Hudetz and D.F. Bruley, Plenum, NY, 1998, pp. 629-634.
21. Secomb, T.W., Hsu, R., Braun, R.D. and
Dewhirst, M.W. Analysis of oxygen transport to tumors: causes of heterogeneous
tissue oxygenation. In Proceedings of the 1999 Bioengineering Conference, ed.
V.K. Goel, R.L. Spilker, G.A. Ateshian and L.J. Soslowsky, ASME, New York, pp.
487-488.
22. Pries, A.R. and Secomb, T.W.. Microvascular adaptation - regulation,
coordination and function. Z. Kardiol 89: Suppl. 9, IX/117-130, 2000.
23. El-Kareh, A.W. and Secomb, T.W. Comparison of intraperitoneal and
intravenous delivery of cisplatin to tumors: a mathematical model. In
Proceedings of the 2001 Bioengineering Conference, ed. R.D. Kamm, G.W.
Schmid-Schonbein, G.A. Ateshian and M.S. Hefzy, ASME, New York, pp. 93-94.
24. Secomb, T.W. and Pries, A.R. Mechanics of shear stress transmission to
endothelial cells in blood vessels lined with an endothelial surface layer. In
Proceedings of the 2001 Bioengineering Conference, ed. R.D. Kamm, G.W. Schmid-Schonbein,
G.A. Ateshian and M.S. Hefzy, ASME, New York, pp. 389-390.
25. McGuire, B.J. and Secomb, T.W. A theoretical model for oxygen transport in
skeletal muscle: factors determining maximal oxygen consumption. In Proceedings
of the 2001 Bioengineering Conference, ed. R.D. Kamm, G.W. Schmid-Schonbein,
G.A. Ateshian and M.S. Hefzy, ASME, New York, pp. 457-458.
26. Secomb, T.W., Reglin, B. and Pries, A.R. Functional and nonfunctional
networks: Reactions to metabolic and hemodynamic stimuli. In "Seventh World
Congress for Microcirculation, Submitted Papers." Monduzzi Editore,
Bologna, Italy, 2001, pp. 203-207.
27. Secomb, T.W. and Pries, A.R. The blood vasculature as an adaptive system:
Role of mechanical sensing. In Sensors and Sensing in Biology and Engineering,
ed. F.G. Barth, J.A.C. Humphrey and T.W. Secomb, Springer-Verlag Wien, 2003,
pp. 187-196.
28. Secomb, T.W. Mechanics of red blood cells and blood flow in narrow tubes.
In Hydrodynamics of Capsules and Cells, ed. C. Pozrikidis, Chapman &
Hall/CRC, Boca Raton, Florida, 2003, pp. 163-196.
29. El-Kareh, A.W. and Secomb, T.W. Theoretical analyses and simulations of
anticancer drug delivery. In Drug Delivery Systems in Cancer Therapy, ed. D.M.
Brown, Humana Press, Totowa NJ 2003, pp. 25-43.
30. Secomb, T.W., Hsu, R. and Pries, A.R. The endothelial surface layer as a
mechanical buffer: Effects on stresses experienced by endothelial cells and red
blood cells in capillary flow. In Proceedings of the 2003 Summer Bioengineering
Conference, ed. L. J. Soslowsky, T.C. Skalak, J. S. Wayne and G. A. Livesay,
pp. 391-392.
31. Secomb, T.W., Styp-Rekowska, B. and Pries, A.R. Computational simulation
of red blood cell deformation and radial migration in microvessels. In Proceedings of the Fifth International
Conference on CFD in the Process Industries, ed. P. J. Witt and M.P. Schwarz.
Book
Reviews
1. "An Introduction to
Mathematical Physiology and Biology" by J. Mazumdar. Review by T.W. Secomb, J. Fluid Mech. 210,
659-660, 1990.
Commentaries
and Letters
1. Pries, A.R. and Secomb, T.W.
Response to commentary: Resistance to blood flow in vivo: from
Poiseuille to the ‘in vivo viscosity law.’
Biorheology 34: 369-375, 1997.
2. Secomb, T.W. Comments on
Point:Counterpoint "Positive effects of intermittent hypoxia (live
high:train low) on exercise performance are/are not mediated primarily by
augmented red cell volume". J Appl Physiol 99:2454-2455, 2005.
3. Dewhirst, M.W., Cardenas Navia,
Updated