Timothy W.
Secomb, Ph.D.
Microvascular networks: 3D structural information
Our simulations of oxygen transport to
tissue are based on idealized three-dimensional representations of
microvascular configurations. Currently, tissues being studied include skeletal
muscle, brain tissue and tumors. The objective of this site is to make
available information on the structures used in our simulations, for use by
other investigators in this area.
Sharing such information is one of the goals
of the Microcirculation
Physiome Project (Popel et al., Annals of Biomedical Engineering 26, 1998)
which is part of the Physiome Project.
The following 3D network structures are now
available:
· Rat tumor, low
density (1993)
· Rat tumor, high
density (1993)
For the following network in rat mesentery,
information on the topology and segment lengths and diameters is available:
Information on the topology, segment lengths and diameters for two networks, supplying areas of 27 and 54 mm2, containing 546 and 913 vessel segments, and with overall blood flow rates of 402 and 1113 nl/min and for a hypothetical small asymmetric network, containing 23 segments is available in the following file: Networks04.zip. These networks are used in simulations of structural adaptation in the following manuscript: Pries, A.R. and Secomb, T.W. Structural control of vessel diameter and wall thickness in microvascular networks. Submitted.
Our intention in making these data available
is that they can be used for further investigations by other groups. Any
publications or presentations using these data should acknowledge their source
and include citations to the relevant publications, as listed with the
description of each network. Please send your comments to: secomb@u.arizona.edu
Our publications showing simulations of
oxygen transport by networks of microvessels include:
Hsu, R. and Secomb, T.W. Analysis of oxygen
exchange between arterioles and surrounding capillary-perfused tissue. J.
Biomech.
Secomb, T.W., Hsu, R., Dewhirst, M.W.,
Klitzman, B. and Gross, J.F. Analysis of oxygen transport to tumor tissue by
microvascular networks. Int. J. Rad. Onc. Biol. Phys. 25: 481-489 (1993).
Secomb, T.W. and Hsu, R. Simulation of
oxygen transport in skeletal muscle: diffusive exchange between arterioles and
capillaries. Am. J. Physiol. 267, H1214-1221 (1994).
Secomb, T.W., Hsu, R., Ong, E.T., Gross,
J.F. and Dewhirst, M.W. Analysis of the effects of oxygen supply and demand on
hypoxic fraction in tumors. Acta Oncologica 34, 313-316 (1995).
Secomb, T.W., Hsu, R., Braun, R.D., Ross,
J.R., Gross, J.F. and Dewhirst, M.W. Theoretical simulation of oxygen transport
to tumors by three-dimensional networks of microvessels. In "Oxygen
Transport to Tissue XX," ed. A.G. Hudetz and D.F. Bruley. Plenum,
Secomb, T.W., Hsu, R., Beamer, N.B. and
Coull, B.M. Theoretical simulation of oxygen transport to brain by networks of
microvessels: effects of oxygen supply and demand on tissue hypoxia.
Microcirculation 7, 237-247 (2000).
Kavanagh, B.D., Secomb, T.W., Hsu, R., Lin,
P.-S., Venitz, J. and Dewhirst, M.W.
A theoretical model for the effects of reduced hemoglobin-oxygen
affinity on tumor oxygenation. Int.
J. Rad. Onc. Biol. Phys. 53: 172-179 (2002).
Secomb, T.W., Hsu, R. and Dewhirst,
M.W. Synergistic effects of
hyperoxic gas breathing and reduced oxygen consumption on tumor
oxygenation: A theoretical
model. Int. J. Rad. Onc. Biol.
Phys., 59: 572-578 (2004).
Secomb, T.W., Hsu, R., Park, E.Y.H. and
Dewhirst, M.W. Green's function
methods for analysis of oxygen delivery to tissue by microvascular
networks. Annals of Biomedical
Engineering, 32: 1519-1529 (2004).
The following is the first of several papers
on the structure and hemodynamics of microvascular networks in the rat
mesentery:
Pries, A.R., Secomb, T.W., Gaehtgens, P. and
Gross, J.F. Blood flow in microvascular networks - Experiments and simulation.
Circulation Research 67: 826-834 (1990).
Updated 26 May 2005